General Cell Based Assays
Eurofins Discoverx PathHunter eXpress GRPR U2OS β-Arrestin GPCR Assay, 2-Plate Kit. (93-0229E3CP5M)
The PathHunter GRPR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. gastrin-releasing peptide) based activation of GRPR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GRPR and EA-tagged β-Arrestin-2. Activation of GRPR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress TRHR CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0239E2CP0M)
The PathHunter TRHR eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. TRH) based activation of TRHR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged TRHR and EA-tagged β-Arrestin-2. Activation of TRHR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress AGTRL1 CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0250E2CP0M)
The PathHunter AGTRL1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. apelin-13) based activation of AGTRL1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged AGTRL1 and EA-tagged β-Arrestin-2. Activation of AGTRL1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress GALR1 CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0228E2CP0M)
The PathHunter GALR1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. galanin) based activation of GALR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GALR1 and EA-tagged β-Arrestin-2. Activation of GALR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CCR10 U2OS β-Arrestin GPCR Assay, 2-Plate Kit. (93-0276E3CP5M)
The PathHunter CCR10 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g.CCL27/CTACK ) based activation of CCR10 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CCR10 and EA-tagged β-Arrestin-2. Activation of CCR10 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CCR10 U2OS β-Arrestin GPCR Assay, 10-Plate Kit. (93-0276E3CP5L)
The PathHunter CCR10 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g.CCL27/CTACK ) based activation of CCR10 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CCR10 and EA-tagged β-Arrestin-2. Activation of CCR10 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress F2R (PAR1) CHO-K1 β-Arrestin GPCR Assay, 10pl Kit. (93-0278E2CP0L)
The PathHunter F2R (PAR1) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. proteases, TFLLRN) based activation of F2R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged F2R and EA-tagged β-Arrestin-2. Activation of F2R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress F2R (PAR1) CHO-K1 β-Arrestin GPCR Assay, 2pl Kit. (93-0278E2CP0M)
The PathHunter F2R (PAR1) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. proteases, TFLLRN) based activation of F2R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged F2R and EA-tagged β-Arrestin-2. Activation of F2R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CCR5 Activated GPCR Internalization Assay, 2-Plate Kit. (93-0653E3CP0M)
The PathHunter CCR5 Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of CCR5 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged CCR5. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting CCR5-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress GPR15 CHO-K1 β-Arrestin Orphan GPCR Assay, 10-Plate Kit. (93-0682E2CP1L)
The PathHunter GPR15 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand based activation of GPR15 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR15 and EA-tagged β-Arrestin-2. Activation of GPR15 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. This is an orphan receptor without a known ligand. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress BDKRB1 CHO-K1 β-Arrestin GPCR Assay, 2-Plate Kit. (93-0639E2CP2M)
The PathHunter BDKRB1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. bradykinin) based activation of BDKRB1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged BDKRB1 and EA-tagged β-Arrestin-2. Activation of BDKRB1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress IL1RL1/IL1RAP Dimerization Assay, 2pl Kit. (93-1067E3CP5M)
The PathHunter IL1RL1/IL1RAP Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IL-33) induced dimerization of IL1RL1/IL1RAP receptors. This product uses EFC technology. The cell line included overexpresses IL1RL1 target protein fused to PK alongside IL1RAP target protein fused to EA. Upon ligand-induced dimerization of IL1RL1/IL1RAP, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress TBXA2R U2OS β-Arrestin GPCR Assay, 2-Plate Kit. (93-0322E3CP5M)
The PathHunter TBXA2R eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. thromboxane A2, prostaglandins) based activation of TBXA2R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged TBXA2R and EA-tagged β-Arrestin-2. Activation of TBXA2R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Revvity Health Sciences Inc HTRF Human IL-2 Detection Kit Standard, 3 Vials
HTRF Human IL-2 Detection Kit Standard, 3 Vials
Eurofins Discoverx PathHunter eXpress IL6RA/IL6ST Dimerization Assay, 2pl Kit. (93-1045E3CP5M)
The PathHunter IL6RA/IL6ST Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. IL-6) induced dimerization of IL6RA/IL6ST receptors. This product uses EFC technology. The cell line included overexpresses IL6ST target protein fused to PK alongside IL6RA target protein fused to EA. Upon ligand-induced dimerization of IL6RA/IL6ST, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.